Services
Medicinal Chemistry
Drug Discovery
Design & Synthesis
- For a given target/drug structure, design a new chemical entity with independent intellectual property rights based on a full understanding of intellectual property rights in the relevant field, combine the principles of medicinal chemistry, computer-aided drug design, etc., and review the literature to design a synthetic route, and finally synthesize the target molecule.
SAR
- Investigate the relationship between structure and activity by testing the biological activity of new chemical entities with different structures, and guide the next round of structure design.
Lead
- Molecules with excellent biological activity and good initial safety profile (hERG, Mini-Ames) are proposed as lead compounds.
Druggability
- Further structural optimization of lead compounds and systematic druggability studies, including: biological activity, pharmacokinetic properties, safety pharmacology, physical and chemical properties, etc.
PCC
- Based on the results of systematic druggability studies, the best molecules were selected as preclinical candidates, while 1-2 structurally differentiated molecules were selected as alternative.
Custom Synthesis
- Customization of New Chemical Entities (NCE)
- Preparation of special reagents, intermediates and molecular fragments
- Synthetic design and preparation of impurities or metabolites
- Synthesis of deuterated compounds
